@article{10.22454/PRiMER.2022.276354,
author = {Indelicato, Alyssa M. and Mohamed, Zacharia H. and Dewan, Mantosh J. and Morley, Christopher P.},
title = {Rapid Antigen Test Sensitivity for Asymptomatic COVID-19 Screening},
journal = {PRiMER},
volume = {6},
year = {2022},
month = {6},
doi = {10.22454/PRiMER.2022.276354},
abstract = {Introduction: Operating in-person instruction, residential living, and other activities at institutions of higher education (IHEs) in the context of the pandemic of severe acute respiratory syndrome—coronavirus 2 (SARS-CoV-2) have posed a multitude of challenges. Identification of asymptomatic cases at IHEs is crucial, as a large reservoir of virus can potentially develop among students. Unfortunately, despite the advantages, rapid antigen tests (RATs) have variously been shown to perform poorly when used with asymptomatic individuals. 
Methods: In order to address the appropriateness of RAT use in screening asymptomatic populations like those at IHEs, we conducted a rapid review of published evaluations of RATs available in the United States, where sensitivity and specificity were reported specifically from asymptomatic populations. We extracted sensitivity and specificity for asymptomatic populations reported in each article, along with location and important notes. The data are presented narratively.
Results: A total of 11 articles were included for evaluation and presentation, representing tests from four manufacturers. Sensitivity ranged from 35.8% to a high of about 71%, with caveats to the higher number about exposure. Both the low and high sensitivity rates were observed in Abbott BinaxNOW RATs. Due to heterogeneity and publishing differences, a meta-analysis was not feasible, but RAT tests in asymptomatic populations tended to identify roughly half of those identified as infected via reverse transcription-polymerase chain reaction. Specificity ranged from 97.8% to 100%.
Conclusion: The results of this rapid review indicate serious issues in misidentifying asymptomatic individuals as COVID-19 negative, when in fact they are infected and carrying the SARS-CoV-2 virus.},
URL = {https://journals.stfm.org//primer/2022/indelicato-2022-0025/},
eprint = {https://journals.stfm.org//media/4933/primer-6-18.pdf},
}